Bovine parainfluenza 3 virus cDNA and Antigen

Bovine parainfluenza 3 virus (BPIV3) is a type of virus that infects cattle and can cause respiratory disease. BPIV3 is a member of the Paramyxoviridae family and is closely related to other viruses that cause respiratory disease in humans and animals, such as human parainfluenza virus and canine parainfluenza virus. BPIV3 infection typically results in a mild to moderate respiratory illness characterized by coughing, nasal discharge, and fever. In some cases, BPIV3 can cause more severe disease, including pneumonia, and can lead to significant economic losses for cattle producers. Control of BPIV3 infection is typically achieved using vaccines and biosecurity measures, such as minimizing the spread of the virus from infected to susceptible animals.

Bovine parainfluenza 3 virus (BPIV3) antigen refers to any substance present on or produced by the BPIV3 virus that elicits an immune response in infected cattle. Antigens on the surface of the BPIV3 virus, such as the virus envelope proteins, are typically recognized by the host immune system and stimulate the production of specific antibodies. These antibodies help to protect the host from reinfection and limit the spread of the virus. In the context of vaccines, BPIV3 antigens are used to stimulate the production of protective antibodies, providing immunity to BPIV3 infection. Understanding the BPIV3 antigens that are most important for eliciting a protective immune response is critical for the development of effective vaccines and for improving the control of BPIV3 infections in cattle.

Bovine parainfluenza virus (BPIV) is a type of virus that can cause respiratory disease in cattle, including fever, coughing, and nasal discharge.

The virus has several proteins, including the matrix protein, nucleoprotein, protein C, and hemagglutinin-neuraminidase.

Bovine Parainfluenza 3 Virus (BPI3V) is a respiratory virus that affects cattle worldwide. It is a member of the Paramyxoviridae family and has several key proteins that play essential roles in the virus’s replication and pathogenesis.

The Matrix protein is a structural protein that plays a crucial role in virus assembly and is involved in regulating viral gene expression. The Nucleoprotein is a viral protein that encapsidates the viral RNA and is involved in virus replication. The Protein C is a nonstructural protein that regulates viral gene expression and is involved in modulating host cell responses.

The Hemagglutinin-Neuraminidase is a viral surface protein that is involved in virus attachment, fusion, and release. Understanding the functions of these proteins is critical for developing diagnostic tests and treatments for BPI3V infections.

Currently, control measures for BPI3V rely on identifying and removing infected animals from the herd. Vaccines are also available to help prevent infection in uninfected cattle. Ongoing research is focused on developing more effective strategies for controlling the virus and minimizing its impact on animal health.

By increasing our knowledge of BPI3V and its key proteins, we can continue to improve animal health and minimize the impact of this virus on cattle populations. Stay informed about the latest research on BPI3V and its impact on animal health.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.