Bovine papular stomatitis virus cDNA and Antigen

Bovine papular stomatitis virus (BPSV) is a virus that infects cattle and causes a skin disease called papular stomatitis. BPSV is a member of the family Poxviridae and has a double-stranded DNA genome. The virus infects the oral mucosa and skin, causing the formation of small, raised, wart-like lesions. These lesions are usually benign and self-limiting, and typically resolve within a few weeks. BPSV is primarily spread through direct contact with infected animals or contaminated fomites, and control measures include maintaining biosecurity, testing, and culling infected animals. BPSV is a low-pathogenic virus and is not known to cause significant economic losses. However, BPSV can cause cosmetic damage to cattle and reduce the value of hides and leather products.

BPSV has a viral envelope that contains several antigens, including the p37K protein.

The p37K protein is a viral envelope antigen that is involved in the attachment and entry of the virus into host cells. It is also essential for virus replication and assembly. Understanding the functions of this protein is critical for developing diagnostic tests and treatments for BPSV infections.

Currently, control measures for BPSV rely on identifying and removing infected animals from the herd. Vaccines are also available to help prevent infection in uninfected cattle. Ongoing research is focused on developing more effective strategies for controlling the virus and minimizing its impact on animal health.

By increasing our knowledge of BPSV and its viral envelope antigen p37K, we can continue to improve animal health and minimize the impact of this virus on cattle populations. Stay informed about the latest research on BPSV and its impact on animal health.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.

Bovine papular stomatitis virus (BPSV) cDNA and recombinant antigen can be used in research to study the virus and its effects on cattle. BPSV is a virus that causes lesions on the lips, mouth, and tongue of cattle, leading to decreased feed intake, weight loss, and increased susceptibility to secondary infection. The cDNA can be used to identify and characterize the virus, while the recombinant antigen can be used to develop a diagnostic test or vaccine. The cDNA can also be used to produce transgenic animals that express the antigen. This could be useful in studies of the virus’ pathology and epidemiology. Additionally, it could be used to develop genetically modified animals that are resistant to the virus.