Clonorchis sinensis is a parasitic flatworm that is primarily found in East Asia and is known to infect the liver and bile ducts of humans and other mammals, causing a range of symptoms including abdominal pain, jaundice, and liver cirrhosis.

Antigen Cs44 and egg protein are key antigens associated with Clonorchis sinensis. Antigen Cs44 is expressed on the surface of the worm and is involved in the modulation of the host immune response. Egg protein is found in the eggs produced by the female worm and is involved in the development of the worm’s egg.

Understanding the function and interaction of the key antigens associated with Clonorchis sinensis is crucial for the development of effective diagnostic tests and vaccines to prevent and control the spread of diseases caused by this parasite. Further research on these antigens could potentially lead to the development of new treatment options for Clonorchis sinensis infections.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.