Products

Onchocerca volvulus cDNA and recombinant antigen

Cat#	Products (Recombinant protein)	Swiss Prot#	Size	Price (US$)	Order
PL0374	Recombinant protein-Onchocerca volvulus Antigen maltose binding protein (a.a.18 to 109)	Q9TY65	100 µg	1195	Order
PL0375	Recombinant protein-Onchocerca volvulus OV39 antigen (a.a.18 to 115)	P31730	100 µg	1195	Order
PL0376	Recombinant protein-Onchocerca volvulus Intermediate filament protein (a.a.61 to 460)	Q7JQ61	100 µg	1195	Order
PL0377	Recombinant protein-Onchocerca volvulus AS1 protein (a.a.28 to 95)	Q25625	100 µg	1195	Order
PL0378	Recombinant protein-Onchocerca volvulus Major antigen (a.a.61 to 460)	P21249	100 µg	1195	Order
PL0379	Recombinant protein-Onchocerca volvulus OV-16 antigen (a.a.16 to 197)	P31729	100 µg	1195	Order
PL0380	Recombinant protein-Onchocerca volvulus Activation-associated secreted protein-1 (a.a.20 to 220)	O16854	100 µg	1195	Order
PL0381	Recombinant protein-Onchocerca volvulus Activation-associated secreted protein-2 (a.a.17 to 224)	Q9GPN4	100 µg	1195	Order
PL0382	Recombinant protein-Onchocerca volvulus OV-17 antigen-Immunodominant hypodermal antigen (a.a.15 to 164)	P36991	100 µg	1195	Order
PL0383	Recombinant protein-Onchocerca volvulus Calreticulin 41 kDa larval antigen (a.a.21 to 388)	P11012	100 µg	1195	Order
PL0384	Recombinant protein-Onchocerca volvulus B20 protein (a.a.31 to 460)	Q25628	100 µg	1195	Order
PL0385	Recombinant protein-Onchocerca volvulus Beta-galactoside-binding lectin (a.a.31 to 280)	Q25597	100 µg	1195	Order
PL0386	Recombinant protein-Onchocerca volvulus protective antigen (a.a.18 to 132)	O45042	100 µg	1195	Order
PL0387	Recombinant protein-Onchocerca volvulus Fatty-acid and retinol-binding protein 1 (a.a.16 to 178)	Q25619	100 µg	1195	Order
PL0388	Recombinant protein-Onchocerca volvulus endobacterium Surface protein (a.a.18 to 152)	Q9FBF6	100 µg	1195	Order
PL0389	Recombinant protein-Onchocerca volvulus endobacterium Cell division protein ftsZ (a.a.29 to 237)	Q9FBF4	100 µg	1195	Order
PL0390	Recombinant protein-Onchocerca volvulus endobacterium Wolbachia Surface Protein (WSP) (a.a.32 to 241)	Q0RAI4	100 µg	1195	Order
RPL0374	cDNA-Onchocerca volvulus Antigen maltose binding protein (a.a.18 to 109)	Q9TY65	2 µg	800	Order
RPL0375	cDNA-Onchocerca volvulus OV39 antigen (a.a.18 to 115)	P31730	2 µg	800	Order
RPL0376	cDNA-Onchocerca volvulus Intermediate filament protein (a.a.61 to 460)	Q7JQ61	2 µg	2394	Order
RPL0377	cDNA-Onchocerca volvulus AS1 protein (a.a.28 to 95)	Q25625	2 µg	402	Order
RPL0378	cDNA-Onchocerca volvulus Major antigen (a.a.61 to 460)	P21249	2 µg	2394	Order
RPL0379	cDNA-Onchocerca volvulus OV-16 antigen (a.a.16 to 197)	P31729	2 µg	1086	Order
RPL0380	cDNA-Onchocerca volvulus Activation-associated secreted protein-1 (a.a.20 to 220)	O16854	2 µg	1200	Order
RPL0381	cDNA-Onchocerca volvulus Activation-associated secreted protein-2 (a.a.17 to 224)	Q9GPN4	2 µg	1242	Order
RPL0382	cDNA-Onchocerca volvulus OV-17 antigen-Immunodominant hypodermal antigen (a.a.15 to 164)	P36991	2 µg	894	Order
RPL0383	cDNA-Onchocerca volvulus Calreticulin 41 kDa larval antigen (a.a.21 to 388)	P11012	2 µg	2202	Order
RPL0384	cDNA-Onchocerca volvulus B20 protein (a.a.31 to 460)	Q25628	2 µg	2574	Order
RPL0385	cDNA-Onchocerca volvulus Beta-galactoside-binding lectin (a.a.31 to 280)	Q25597	2 µg	1494	Order
RPL0386	cDNA-Onchocerca volvulus protective antigen (a.a.18 to 132)	O45042	2 µg	800	Order
RPL0387	cDNA-Onchocerca volvulus Fatty-acid and retinol-binding protein 1 (a.a.16 to 178)	Q25619	2 µg	972	Order
RPL0388	cDNA-Onchocerca volvulus endobacterium Surface protein (a.a.18 to 152)	Q9FBF6	2 µg	804	Order
RPL0389	cDNA-Onchocerca volvulus endobacterium Cell division protein ftsZ (a.a.29 to 237)	Q9FBF4	2 µg	1248	Order
RPL0390	cDNA-Onchocerca volvulus endobacterium Wolbachia Surface Protein (WSP (a.a.32 to 241)	Q0RAI4	2 µg	1254	Order

Please contact us for a quote on larger sizes …

Onchocerca volvulus cDNA and recombinant antigen

Codon-optimized cDNA is cloned into E. coli expression vector with 6x His-tag at N-terminus and ready-to-use for recombinant protein production.
Recombinant protein applications: Western Blot may be used for other applications determined by the user.
Protein Purity: >90%, as determined by SDS-PAGE under reducing conditions.
Protein Activity: N/A
Protein Tag: Contains A 6x histidine tag at N-terminus.
Protein Formulation: Liquid
Source: Produced from E. coli

Onchocerca volvulus is a parasitic nematode that causes onchocerciasis, also known as river blindness. It is transmitted to humans through the bites of black flies of the genus Simulium. The disease is endemic in many parts of Africa, as well as in parts of Latin America and Yemen. There is no vaccine for onchocerciasis, and current treatments are limited to control the symptoms of the disease.

Research is ongoing to identify potential antigens that could be used for the diagnosis and treatment of onchocerciasis. Some of the important antigens identified in Onchocerca volvulus include:

OV-16 and OV-17 antigens: These are major diagnostic antigens that are used in serological tests for the detection of onchocerciasis.
B20 protein: This is a protective antigen that has been shown to induce partial protection against Onchocerca infection in animal models.
Calreticulin: This antigen is a 41 kDa larval antigen that has been identified as a target of human immune responses to Onchocerca volvulus. It is being researched for its potential use in the diagnosis of onchocerciasis.

Other antigens that have been identified in Onchocerca volvulus include activation-associated secreted protein-1 and 2, beta-galactoside-binding lectin, fatty-acid and retinol-binding protein 1, and several endobacterium proteins such as surface protein, cell division protein ftsZ, and Wolbachia surface protein (WSP).

Research on these antigens is ongoing and may lead to the development of new diagnostic tools and treatments for onchocerciasis.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.

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Onchocerca volvulus cDNA and recombinant antigen

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