Campylobacter fetus is a Gram-negative bacterium that can cause a range of diseases in animals and humans, including gastroenteritis, septicemia, and abortion in livestock. In humans, it can cause a range of symptoms such as fever, diarrhea, and abdominal pain.

Campylobacter invasion antigen B and subfetus-Herring worm protein are key antigens associated with Campylobacter fetus. Campylobacter invasion antigen B plays a crucial role in the invasion of host cells by Campylobacter fetus and has been identified as a potential target for the development of vaccines and diagnostic tests. Subfetus-Herring worm protein is involved in the attachment of Campylobacter fetus to host cells and is also a potential target for vaccine development.

Understanding the function and interaction of the key antigens associated with Campylobacter fetus is crucial for the development of effective diagnostic tests and vaccines to prevent and control the spread of diseases caused by this bacterium in animals and humans.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.