Products

Brugia malayi cDNA and recombinant antigen

Cat#

Products (Recombinant protein)

Swiss Prot#

Size

Price (US$)

Order

PL0110

Recombinant protein-Brugia malayi  Gp 15-400 antigen (a.a.1 to 132)

Q26405

100 µg

1195

Order

PL0111

Recombinant protein-Brugia malayi  Filarial antigen (a.a.30 to 461)

Q26442

100 µg

1195

Order

PL0112

Recombinant protein-Brugia malayi  Major antigen (a.a.30 to 255)

A8NZB4

100 µg

1195

Order

PL0113

Recombinant protein-Brugia malayi  Collagen-like antigen (a.a.30 to 452)

Q17189

100 µg

1195

Order

PL0114

Recombinant protein-Brugia malayi  Interspersed repeat antigen (a.a.30 to 386)

A8NLR3

100 µg

1195

Order

PL0115

Recombinant protein-Brugia malayi  LL20 15kDa ladder antigen (a.a.61 to 460)

A8QEB0

100 µg

1195

Order

PL0116

Recombinant protein-Brugia malayi  Sarcoma antigen NY-SAR-91(a.a.1 to 136)

A8NU33

100 µg

1195

Order

PL0117

Recombinant protein-Brugia malayi  Major surface protein 3(a.a.30 to 294)

A8PZD8

100 µg

1195

Order

PL0118

Recombinant protein-Brugia malayi  CLL-associated antigen KW-2(a.a.30 to 480)

A8PQV9

100 µg

1195

Order

PL0119

Recombinant protein-Brugia malayi  Proliferating cell nuclear antigen (a.a.30 to 264)

A8PV43

100 µg

1195

Order

PL0120

Recombinant protein-Brugia malayi  OV39 antigen-like (a.a.1 to 135)

A8NVF8

100 µg

1195

Order

PL0121

Recombinant protein-Brugia malayi  Cutaneous T-cell lymphoma tumor antigen se70-2(a.a.61 to 460)

A8Q8D6

100 µg

1195

Order

PL0122

Recombinant protein-Brugia malayi  Recombinant antigen R1 (a.a.26 to 206)

Q71TT6

100 µg

1195

Order

PL0123

Recombinant protein-Brugia malayi  S-antigen protein (a.a.30 to 262)

A8NI25

100 µg

1195

Order

PL0124

Recombinant protein-Brugia malayi  Antigen (a.a.15 to 155)

A8Q4D7

100 µg

1195

Order

PL0125

Recombinant protein-Brugia malayi  Filarial antigen Av33 (a.a.21 to 223)

A8Q4E4

100 µg

1195

Order

PL0126

Recombinant protein-Brugia malayi  Antigen-L3SXP (a.a.17 to 153)

A8Q4D9

100 µg

1195

Order

PL0127

Recombinant protein-Brugia malayi  Venom allergen antigen-like protein 1 (a.a.30 to 220)

O44932

100 µg

1195

Order

PL0128

Recombinant protein-Brugia malayi  Microfilariae surface-associated protein (a.a.21 to 107)

A8NFN8

100 µg

1195

Order

PL0129

Recombinant protein-Brugia malayi  Membrane-anchored cell surface protein (a.a.20 to 250)

A8Q5R4

100 µg

1195

Order

PL0130

Recombinant protein-Brugia malayi  Recombinant antigen R1- identical (a.a.22 to 203)

A8NW22

100 µg

1195

Order

PL0131

Recombinant protein-Brugia malayi  Immunodominant antigen homologue (a.a.61 to 460)

A8PQT5

100 µg

1195

Order

PL0132

Recombinant protein-Brugia malayi  Serologically defined colon cancer antigen 1(a.a.19 to 307)

A8NVV9

100 µg

1195

Order

PL0133

Recombinant protein-Brugia malayi  Cuticular glycoprotein gp29 (a.a.26 to 223)

P67877

100 µg

1195

Order

PL0134

Recombinant protein-Brugia malayi  Hepatocellular carcinoma-associated antigen 66(a.a.1 to 103)

A8NUF5

100 µg

1195

Order

PL0135

Recombinant protein-Brugia malayi  IgG and IgE immunoreactive antigen (a.a.14 to 175)

A8NZ92

100 µg

1195

Order

PL0136

Recombinant protein-Brugia malayi  Hepatocellular carcinoma-associated antigen (a.a.30 to 426)

A8NKY4

100 µg

1195

Order

PL0137

Recombinant protein-Brugia malayi  Serologically defined breast cancer antigen (a.a.30 to 341)

A8PT78

100 µg

1195

Order

PL0138

Recombinant protein-Brugia malayi  OV-16 antigen (a.a.20 to 185)

A8Q2C4

100 µg

1195

Order

PL0139

Recombinant protein-Brugia malayi  Octapeptide-repeat antigen (a.a.25 to 111)

A8PMZ0

100 µg

1195

Order

PL0140

Recombinant protein-Brugia malayi  60K filarial antigen-nematode (a.a.30 to 491)

A8QF57

100 µg

1195

Order

PL0141

Recombinant protein-Brugia malayi  Merozoite surface protein 2(a.a.14 to 149)

A8PIT0

100 µg

1195

Order

RPL0110

cDNA-Brugia malayi Gp 15-400 antigen (a.a.1 to 132)

Q26405

2 µg

786

Order

RPL0111

cDNA-Brugia malayi  Filarial antigen (a.a.30 to 461)

Q26442

2 µg

2586

Order

RPL0112

cDNA-Brugia malayi  Major antigen (a.a.30 to 255)

A8NZB4

2 µg

1350

Order

RPL0113

cDNA-Brugia malayi  Collagen-like antigen (a.a.30 to 452)

Q17189

2 µg

2532

Order

RPL0114

cDNA-Brugia malayi  Interspersed repeat antigen (a.a.30 to 386)

A8NLR3

2 µg

2136

Order

RPL0115

cDNA-Brugia malayi  LL20 15kDa ladder antigen (a.a.61 to 460)

A8QEB0

2 µg

2394

Order

RPL0116

cDNA-Brugia malayi  Sarcoma antigen NY-SAR-91(a.a.1 to 136)

A8NU33

2 µg

810

Order

RPL0117

cDNA-Brugia malayi  Major surface protein 3(a.a.30 to 294)

A8PZD8

2 µg

1584

Order

RPL0118

cDNA-Brugia malayi  CLL-associated antigen KW-2(a.a.30 to 480)

A8PQV9

2 µg

2700

Order

RPL0119

cDNA-Brugia malayi  Proliferating cell nuclear antigen (a.a.30 to 264)

A8PV43

2 µg

1404

Order

RPL0120

cDNA-Brugia malayi  OV39 antigen-like (a.a.1 to 135)

A8NVF8

2 µg

804

Order

RPL0121

cDNA-Brugia malayi  Cutaneous T-cell lymphoma tumor antigen se70-2(a.a.61 to 460)

A8Q8D6

2 µg

2394

Order

RPL0122

cDNA-Brugia malayi  Recombinant antigen R1 (a.a.26 to 206)

Q71TT6

2 µg

1080

Order

RPL0123

cDNA-Brugia malayi  S-antigen protein (a.a.30 to 262)

A8NI25

2 µg

1392

Order

RPL0124

cDNA-Brugia malayi  Antigen (a.a.15 to 155)

A8Q4D7

2 µg

840

Order

RPL0125

cDNA-Brugia malayi  Filarial antigen Av33 (a.a.21 to 223)

A8Q4E4

2 µg

1212

Order

RPL0126

cDNA-Brugia malayi  Antigen-L3SXP (a.a.17 to 153)

A8Q4D9

2 µg

816

Order

RPL0127

cDNA-Brugia malayi  Venom allergen antigen-like protein 1 (a.a.30 to 220)

O44932

2 µg

1140

Order

RPL0128

cDNA-Brugia malayi  Microfilariae surface-associated protein (a.a.21 to 107)

A8NFN8

2 µg

800

Order

RPL0129

cDNA-Brugia malayi  Membrane-anchored cell surface protein (a.a.20 to 250)

A8Q5R4

2 µg

1380

Order

RPL0130

cDNA-Brugia malayi  Recombinant antigen R1- identical (a.a.22 to 203)

A8NW22

2 µg

1086

Order

RPL0131

cDNA-Brugia malayi  Immunodominant antigen homologue (a.a.61 to 460)

A8PQT5

2 µg

2394

Order

RPL0132

cDNA-Brugia malayi  Serologically defined colon cancer antigen 1(a.a.19 to 307)

A8NVV9

2 µg

1728

Order

RPL0133

cDNA-Brugia malayi  Cuticular glycoprotein gp29 (a.a.26 to 223)

P67877

2 µg

1182

Order

RPL0134

cDNA-Brugia malayi  Hepatocellular carcinoma-associated antigen 66(a.a.1 to 103)

A8NUF5

2 µg

800

Order

RPL0135

cDNA-Brugia malayi  IgG and IgE immunoreactive antigen (a.a.14 to 175)

A8NZ92

2 µg

966

Order

RPL0136

cDNA-Brugia malayi  Hepatocellular carcinoma-associated antigen (a.a.30 to 426)

A8NKY4

2 µg

2376

Order

RPL0137

cDNA-Brugia malayi  Serologically defined breast cancer antigen (a.a.30 to 341)

A8PT78

2 µg

1866

Order

RPL0138

cDNA-Brugia malayi  OV-16 antigen (a.a.20 to 185)

A8Q2C4

2 µg

990

Order

RPL0139

cDNA-Brugia malayi  Octapeptide-repeat antigen (a.a.25 to 111)

A8PMZ0

2 µg

800

Order

RPL0140

cDNA-Brugia malayi  60K filarial antigen-nematode (a.a.30 to 491)

A8QF57

2 µg

2766

Order

RPL0141

cDNA-Brugia malayi  Merozoite surface protein 2(a.a.14 to 149)

A8PIT0

2 µg

810

Order

Brugia malayi cDNA and recombinant antigen

  • Codon-optimized cDNA is cloned into E. coli expression vector with 6x His-tag at N-terminus and ready-to-use for recombinant protein production.
  • Recombinant protein applications: Western Blot may be used for other applications determined by the user.
  • Protein Purity: >90%, as determined by SDS-PAGE under reducing conditions.
  • Protein Activity: N/A
  • Protein Tag:  Contains A 6x histidine tag at N-terminus.
  • Protein Formulation: Liquid
  • Source: Produced from E. coli

Brugia malayi is a filarial nematode that is transmitted by mosquitoes and causes lymphatic filariasis, a disease that can lead to debilitating swelling of the limbs and genitals. It is endemic to certain regions of the world and is a major public health concern in many developing countries.

Gp 15-400 antigen, major antigens, and filarial antigens are key targets in the development of diagnostic tests and vaccines for lymphatic filariasis. Some of the major antigens of Brugia malayi include collagen-like antigen, interspersed repeat antigen, LL20 15kDa ladder antigen, and sarcoma antigen NY-SAR-91. Filarial antigens such as Av33, major surface protein 3, CLL-associated antigen KW-2, proliferating cell nuclear antigen, OV39 antigen-like, recombinant antigen R1, S-antigen protein, L3SXP, venom allergen antigen-like protein 1, gp29, OV-16 antigen, and 60K filarial antigen-nematode are also potential targets for diagnostic tests and vaccines.

Understanding the function and interaction of the key antigens associated with Brugia malayi is crucial for the development of effective diagnostic tests and vaccines to prevent and control the spread of lymphatic filariasis.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.

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