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Cat# | Products (Recombinant protein) | Swiss Prot# | Size | Price (US$) | Order |
PL0033 | Recombinant protein-Babesia bovis Variant erythrocyte surface antigen-1 subunit 1a (a.a.21 to 166) | C1JCT9 | 100 µg | 1195 | |
PL0034 | Recombinant protein-Babesia bovis C9.1 variant erythrocyte surface antigen-1a (a.a.21 to 195) | Q2LIX5 | 100 µg | 1195 | |
PL0035 | Recombinant protein-Babesia bovis PBS lyase HEAT-like repeat domain containing protein (a.a.31 to 332) | A7AS23 | 100 µg | 1195 | |
PL0036 | Recombinant protein-Babesia bovis Variant erythrocyte surface antigen-1 (a.a.61 to 460) | A7AMT6 | 100 µg | 1195 | |
PL0037 | Recombinant protein-Babesia bovis Anonymous antigen-3 (Membrane protein- (a.a.61 to 460) | Q2PKG2 | 100 µg | 1195 | |
PL0038 | Recombinant protein-Babesia bovis C9.1 variant erythrocyte surface antigen-1a (a.a.61 to 460) | Q9NJA8 | 100 µg | 1195 | |
PL0039 | Recombinant protein-Babesia bovis Variant erythrocyte surface antigen-1- beta subunit (a.a.61 to 460) | A7ALZ4 | 100 µg | 1195 | |
PL0040 | Recombinant protein-Babesia bovis 200 kDa antigen p200 (a.a.50 to 350) | A7AWC8 | 100 µg | 1195 | |
PL0041 | Recombinant protein-Babesia bovis Hsp90 protein (a.a.61 to 460) | Q9NDI2 | 100 µg | 1195 | |
PL0042 | Recombinant protein-Babesia bovis Merozoite surface antigen-1 (a.a.21 to 339) | Q9BN13 | 100 µg | 1195 | |
PL0043 | Recombinant protein-Babesia bovis Merozoite surface antigen 1 (a.a.15 to 274) | Q4TWG4 | 100 µg | 1195 | |
PL0044 | Recombinant protein-Babesia bovis Variant erythrocyte surface antigen-1(a.a.50 to 350) | A7AXI4 | 100 µg | 1195 | |
PL0045 | Recombinant protein-Babesia bovis Variable antigen 1 (a.a.32 to 370) | Q17117 | 100 µg | 1195 | |
PL0046 | Recombinant protein-Babesia bovis Heat shock protein 75(a.a.61 to 460) | A7ASC2 | 100 µg | 1195 | |
PL0047 | Recombinant protein-Babesia bovis Erythrocyte membrane-associated antigen (a.a.23 to 478) | A7AUS3 | 100 µg | 1195 | |
PL0048 | Recombinant protein-Babesia bovis 41-2 protein antigen (a.a.21 to 159) | A7AUI6 | 100 µg | 1195 | |
PL0049 | Recombinant protein-Babesia bovisSeroreactive antigen BMN1-9B (a.a.31 to 438) | A7ATD7 | 100 µg | 1195 | |
PL0050 | Recombinant protein-Babesia bovis BBO225AA 22 kDa antigen (a.a.30 to 373) | A7AMA7 | 100 µg | 1195 | |
PL0051 | Recombinant protein-Babesia bovis Proliferating cell nuclear antigen (a.a.31 to 264) | A7AUH5 | 100 µg | 1195 | |
PL0052 | Recombinant protein-Babesia bovis Variant erythrocyte surface antigen-1 (a.a.61 to 460) | A7ALY9 | 100 µg | 1195 | |
PL0053 | Recombinant protein-Babesia bovis HEAT repeat (a.a.50 to 350) | A7ATT6 | 100 µg | 1195 | |
PL0054 | Recombinant protein-Babesia bovis Heat shock protein 60(a.a.61 to 460) | A7AR66 | 100 µg | 1195 | |
PL0055 | Recombinant protein-Babesia bovis Merozoite surface antigen 2a1 (a.a.20 to 316) | Q3LUQ3 | 100 µg | 1195 | |
PL0056 | Recombinant protein-Babesia bovis Heat shock protein 70(a.a.61 to 460) | A7AP56 | 100 µg | 1195 | |
PL0057 | Recombinant protein-Babesia bovis RAP-1 related antigen (RRA (a.a.21 to 349) | A7AS63 | 100 µg | 1195 | |
PL0058 | Recombinant protein-Babesia bovis Heat shock protein 90(a.a.61 to 460) | A7ARM5 | 100 µg | 1195 | |
PL0059 | Recombinant protein-Babesia bovis Anonymous antigen-4 (a.a.31 to 232) | Q2PKG1 | 100 µg | 1195 | |
PL0060 | Recombinant protein-Babesia bovis 12D3 antigen (a.a.21 to 346) | A7ARK0 | 100 µg | 1195 | |
PL0061 | Recombinant protein-Babesia bovis Surface protein D (a.a.19 to 156) | A7AV15 | 100 µg | 1195 | |
PL0062 | Recombinant protein-Babesia bovis 41K blood stage antigen 41-3 (a.a.25 to 321) | A7AR21 | 100 µg | 1195 | |
PL0063 | Recombinant protein-Babesia bovis Apical membrane antigen 1 (a.a.38 to 400) | A7ASF6 | 100 µg | 1195 | |
PL0064 | Recombinant protein-Babesia bovis Heat shock protein 90 (a.a.61 to 460) | A7AP15 | 100 µg | 1195 | |
PL0065 | Recombinant protein-Babesia bovis Merozoite surface protein (a.a.61 to 460) | Q17115 | 100 µg | 1195 | |
PL0066 | Recombinant protein-Babesia bovisDnaK protein (a.a.61 to 460) | Q9U545 | 100 µg | 1195 | |
PL0067 | Recombinant protein-Babesia bovis variant erythrocyte surface antigen-1a (a.a.50 to 350) | Q86BU4 | 100 µg | 1195 | |
PL0068 | Recombinant protein-Babesia bovissmall heat shock protein (a.a.21 to 188) | A7ATV2 | 100 µg | 1195 | |
PL0069 | Recombinant protein-Babesia bovis variant erythrocyte surface antigen-1a (a.a.32 to 470) | Q2LIX3 | 100 µg | 1195 | |
PL0070 | Recombinant protein-Babesia bovis variant erythrocyte surface antigen-1a related protein (a.a.61 to 460) | Q2LIX2 | 100 µg | 1195 | |
PL0071 | Recombinant protein-Babesia bovis Heat shock protein 70 (a.a.61 to 460) | A7AVW9 | 100 µg | 1195 | |
PL0072 | Recombinant protein-Babesia bovis Merozoite surface antigen 2 (a.a.21 to 265) | Q3LUM8 | 100 µg | 1195 | |
PL0073 | Recombinant protein-Babesia bovis Variant erythrocyte surface antigen-1(a.a.21 to 182) | A7AXH3 | 100 µg | 1195 | |
PL0074 | Recombinant protein-Babesia bovis Variant erythrocyte surface antigen-1a (a.a.31 to 217) | Q9N636 | 100 µg | 1195 | |
PL0075 | Recombinant protein-Babesia bovis Merozoite surface protein (a.a.54 to 354) | Q17120 | 100 µg | 1195 | |
PL0076 | Recombinant protein-Babesia bovis Merozoite surface antigen-2b (a.a.31 to 225) | A6YRH4 | 100 µg | 1195 | |
RPL0033 | cDNA-Babesia bovis Variant erythrocyte surface antigen-1 subunit 1a (a.a.21 to 166) | C1JCT9 | 2 µg | 870 | |
RPL0034 | cDNA-Babesia bovis C9.1 variant erythrocyte surface antigen-1a (a.a.21 to 195) | Q2LIX5 | 2 µg | 1044 | |
RPL0035 | cDNA-Babesia bovis PBS lyase HEAT-like repeat domain containing protein (a.a.31 to 332) | A7AS23 | 2 µg | 1806 | |
RPL0036 | cDNA-Babesia bovis Variant erythrocyte surface antigen-1 (a.a.61 to 460) | A7AMT6 | 2 µg | 2394 | |
RPL0037 | cDNA-Babesia bovis Anonymous antigen-3 (Membrane protein- (a.a.61 to 460) | Q2PKG2 | 2 µg | 2394 | |
RPL0038 | cDNA-Babesia bovis C9.1 variant erythrocyte surface antigen-1a (a.a.61 to 460) | Q9NJA8 | 2 µg | 2394 | |
RPL0039 | cDNA-Babesia bovis Variant erythrocyte surface antigen-1- beta subunit (a.a.61 to 460) | A7ALZ4 | 2 µg | 2394 | |
RPL0040 | cDNA-Babesia bovis 200 kDa antigen p200 (a.a.50 to 350) | A7AWC8 | 2 µg | 1800 | |
RPL0041 | cDNA-Babesia bovis Hsp90 protein (a.a.61 to 460) | Q9NDI2 | 2 µg | 2394 | |
RPL0042 | cDNA-Babesia bovis Merozoite surface antigen-1 (a.a.21 to 339) | Q9BN13 | 2 µg | 1908 | |
RPL0043 | cDNA-Babesia bovis Merozoite surface antigen 1 (a.a.15 to 274) | Q4TWG4 | 2 µg | 1554 | |
RPL0044 | cDNA-Babesia bovis Variant erythrocyte surface antigen-1(a.a.50 to 350) | A7AXI4 | 2 µg | 1800 | |
RPL0045 | cDNA-Babesia bovis Variable antigen 1 (a.a.32 to 370) | Q17117 | 2 µg | 2028 | |
RPL0046 | cDNA-Babesia bovis Heat shock protein 75(a.a.61 to 460) | A7ASC2 | 2 µg | 2394 | |
RPL0047 | cDNA-Babesia bovis Erythrocyte membrane-associated antigen (a.a.23 to 478) | A7AUS3 | 2 µg | 2730 | |
RPL0048 | cDNA-Babesia bovis 41-2 protein antigen (a.a.21 to 159) | A7AUI6 | 2 µg | 828 | |
RPL0049 | cDNA-Babesia bovisSeroreactive antigen BMN1-9B (a.a.31 to 438) | A7ATD7 | 2 µg | 2442 | |
RPL0050 | cDNA-Babesia bovis BBO225AA 22 kDa antigen (a.a.30 to 373) | A7AMA7 | 2 µg | 2058 | |
RPL0051 | cDNA-Babesia bovis Proliferating cell nuclear antigen (a.a.31 to 264) | A7AUH5 | 2 µg | 1398 | |
RPL0052 | cDNA-Babesia bovis Variant erythrocyte surface antigen-1 (a.a.61 to 460) | A7ALY9 | 2 µg | 2394 | |
RPL0053 | cDNA-Babesia bovis HEAT repeat (a.a.50 to 350) | A7ATT6 | 2 µg | 1800 | |
RPL0054 | cDNA-Babesia bovis Heat shock protein 60(a.a.61 to 460) | A7AR66 | 2 µg | 2394 | |
RPL0055 | cDNA-Babesia bovis Merozoite surface antigen 2a1 (a.a.20 to 316) | Q3LUQ3 | 2 µg | 1776 | |
RPL0056 | cDNA-Babesia bovis Heat shock protein 70(a.a.61 to 460) | A7AP56 | 2 µg | 2394 | |
RPL0057 | cDNA-Babesia bovis RAP-1 related antigen (RRA (a.a.21 to 349) | A7AS63 | 2 µg | 1968 | |
RPL0058 | cDNA-Babesia bovis Heat shock protein 90(a.a.61 to 460) | A7ARM5 | 2 µg | 2394 | |
RPL0059 | cDNA-Babesia bovis Anonymous antigen-4 (a.a.31 to 232) | Q2PKG1 | 2 µg | 1206 | |
RPL0060 | cDNA-Babesia bovis 12D3 antigen (a.a.21 to 346) | A7ARK0 | 2 µg | 1950 | |
RPL0061 | cDNA-Babesia bovis Surface protein D (a.a.19 to 156) | A7AV15 | 2 µg | 822 | |
RPL0062 | cDNA-Babesia bovis 41K blood stage antigen 41-3 (a.a.25 to 321) | A7AR21 | 2 µg | 1776 | |
RPL0063 | cDNA-Babesia bovis Apical membrane antigen 1 (a.a.38 to 400) | A7ASF6 | 2 µg | 2172 | |
RPL0064 | cDNA-Babesia bovis Heat shock protein 90 (a.a.61 to 460) | A7AP15 | 2 µg | 2394 | |
RPL0065 | cDNA-Babesia bovis Merozoite surface protein (a.a.61 to 460) | Q17115 | 2 µg | 2394 | |
RPL0066 | cDNA-Babesia bovisDnaK protein (a.a.61 to 460) | Q9U545 | 2 µg | 2394 | |
RPL0067 | cDNA-Babesia bovis variant erythrocyte surface antigen-1a (a.a.50 to 350) | Q86BU4 | 2 µg | 1800 | |
RPL0068 | cDNA-Babesia bovissmall heat shock protein (a.a.21 to 188) | A7ATV2 | 2 µg | 1002 | |
RPL0069 | cDNA-Babesia bovis variant erythrocyte surface antigen-1a (a.a.32 to 470) | Q2LIX3 | 2 µg | 2628 | |
RPL0070 | cDNA-Babesia bovis variant erythrocyte surface antigen-1a related protein (a.a.61 to 460) | Q2LIX2 | 2 µg | 2394 | |
RPL0071 | cDNA-Babesia bovis Heat shock protein 70 (a.a.61 to 460) | A7AVW9 | 2 µg | 2394 | |
RPL0072 | cDNA-Babesia bovis Merozoite surface antigen 2 (a.a.21 to 265) | Q3LUM8 | 2 µg | 1464 | |
RPL0073 | cDNA-Babesia bovis Variant erythrocyte surface antigen-1(a.a.21 to 182) | A7AXH3 | 2 µg | 966 | |
RPL0074 | cDNA-Babesia bovis Variant erythrocyte surface antigen-1a (a.a.31 to 217) | Q9N636 | 2 µg | 1116 | |
RPL0075 | cDNA-Babesia bovis Merozoite surface protein (a.a.54 to 354) | Q17120 | 2 µg | 1800 | |
RPL0076 | cDNA-Babesia bovis Merozoite surface antigen-2b (a.a.31 to 225) | A6YRH4 | 2 µg | 1164 |
Babesia bovis cDNA and recombinant antigen
Babesia bovis is a tick-borne protozoan parasite that infects cattle, causing babesiosis, a disease that can be fatal if left untreated. The parasite has a complex life cycle that involves multiple stages, and it interacts with a variety of host proteins and antigens to establish and maintain infection.
Some of the most well-known proteins and antigens associated with Babesia bovis include Variant erythrocyte surface antigen-1 subunit 1a, also known as VESA1.1a, which is a major virulence factor that allows the parasite to evade the host immune response. Another important protein is Merozoite surface antigen-1, or MSA-1, which is a target of the host immune response and is being studied as a potential vaccine candidate.
Other notable proteins and antigens include Heat shock protein 75, Apical membrane antigen 1, and RAP-1 related antigen RRA. These proteins play important roles in various stages of the parasite’s life cycle, such as invasion of host cells, evasion of host immunity, and establishment of chronic infection.
In addition to the well-known proteins and antigens associated with Babesia bovis, there are several other proteins and antigens that are being studied for their potential roles in disease pathogenesis and immunity.
For example, Variant erythrocyte surface antigen-1- beta subunit, or VESA1-beta, is a component of the VESA1 protein complex and is thought to be involved in host cell invasion. Another antigen, Apical membrane antigen 2, or AMA-2, has been shown to be a target of the host immune response and is being evaluated as a potential vaccine candidate.
Other proteins of interest include Heat shock proteins, such as Hsp90, DnaK, and small heat shock protein, which are involved in protein folding and play important roles in host-parasite interactions. The 41-2 protein antigen, Anonymous antigen-3, and BBO225AA 22 kDa antigen are also being studied for their potential roles in host immune response and parasite survival.
Overall, understanding the complex interplay between Babesia bovis and its host is critical for developing effective strategies to prevent and treat babesiosis. Ongoing research into the different proteins and antigens associated with this parasite will likely lead to the development of new diagnostics, vaccines, and therapies to combat this important disease.
The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.
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