Streptococcus uberis cDNA and recombinant antigen

Streptococcus uberis is a species of Gram-positive, facultative anaerobic, and nonmotile bacteria. It is a member of the genus Streptococcus, and is typically found in the environment, as well as in the mammalian gastrointestinal tract. It is also found in milk and milk products and is a common cause of mastitis in dairy cows. S. uberis is also an opportunistic pathogen, and is known to cause human infections, although it is not as common as other Streptococcus species.

Streptococcus uberis produces various proteins, including the MtuA and MtuB proteins. The MtuA protein is a virulence factor that is involved in the bacterium’s ability to form biofilms and adhere to host tissues. It has been shown to play a role in the development of bovine mastitis, a common infection of dairy cows caused by S. uberis. The MtuB protein, on the other hand, is involved in the transport of metals into the bacterium and is important for its survival in various environments. Understanding the functions of these proteins is important for developing effective treatments and vaccines against S. uberis infections.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.

The use of cDNA and recombinant antigens derived from this organism can have several potential applications. 1. Diagnostics: cDNA and recombinant antigens derived from S. uberis can be used in the development of diagnostic tests for the detection of infections or colonization of the bacteria. 2. Vaccines: The use of cDNA and recombinant antigens derived from S. uberis can also be used in the development of vaccines against the organism, which can be used to protect against future infections. 3. Therapeutics: Recombinant antigens derived from S. uberis can be used to develop therapeutic proteins that can be used to treat infections caused by the organism. 4. Research: cDNA and recombinant antigens derived from S. uberis can also be used in research to gain a better understanding of the organism and its interaction with other organisms in the environment.