Products

Streptococcus pyogenes cDNA and recombinant antigen

Cat#	Products (Recombinant protein)	Swiss Prot#	Size	Price (US$)	Order
PP0968	Recombinant Protein-Streptococcus pyogenes Fibronectin-fibrinogen-binding protein (a.a.61 to 474)	Q6SPC7	100 µg	1195	Order
PP0969	Recombinant Protein-Streptococcus pyogenes Fibronectin-binding protein II (a.a.61 to 460)	P72532	100 µg	1195	Order
PP0970	Recombinant Protein-Streptococcus pyogenes M protein (a.a.22 to 220)	B7TBG7	100 µg	1195	Order
PP0971	Recombinant Protein-Streptococcus pyogenes M protein 11 (a.a.41 to 386)	Q54829	100 µg	1195	Order
PP0972	Recombinant Protein-Streptococcus pyogenes M protein 19 (a.a.41 to 558)	Q54718	100 µg	1195	Order
PP0973	Recombinant Protein-Streptococcus pyogenes M protein 3 (a.a.41 to 581)	Q54835	100 µg	1195	Order
PP0974	Recombinant Protein-Streptococcus pyogenes M protein 55 (a.a.41 to 550)	Q54840	100 µg	1195	Order
PP0975	Recombinant Protein-Streptococcus pyogenes M protein type 41 (a.a.39 to 408)	Q54837	100 µg	1195	Order
PP0976	Recombinant Protein-Streptococcus pyogenes M protein type 52 (a.a.33 to 436)	Q54839	100 µg	1195	Order
PP0977	Recombinant Protein-Streptococcus pyogenes M protein type 83 (a.a.24 to 85)	Q5XPU8	100 µg	1195	Order
PP0978	Recombinant Protein-Streptococcus pyogenes M protein serotype 2.1 (a.a.40 to 407)	P50468	100 µg	1195	Order
PP0979	Recombinant Protein-Streptococcus pyogenes M protein serotype 2.2 (a.a.33 to 372)	P50469	100 µg	1195	Order
PP0980	Recombinant Protein-Streptococcus pyogenes M protein serotype 24 (a.a.41 to 539)	P12379	100 µg	1195	Order
PP0981	Recombinant Protein-Streptococcus pyogenes M18 protein 18 (a.a.41 to 437)	Q9AMC4	100 µg	1195	Order
PP0982	Recombinant Protein-Streptococcus pyogenes Mitogenic factor (a.a.32 to 271)	Q54969	100 µg	1195	Order
PP0983	Recombinant Protein-Streptococcus pyogenes M-type 9 protein (a.a.33 to 384)	Q54841	100 µg	1195	Order
PP0984	Recombinant Protein-Streptococcus pyogenes steptococcal M PAM (a.a.25 to 388)	P49054	100 µg	1195	Order
PP0985	Recombinant Protein-Streptococcus pyogenes serotype M1 M protein type 1 (a.a.35 to 484)	Q99XV0	100 µg	1195	Order
PP0986	Recombinant Protein-Streptococcus pyogenes serotype M1 42 kDa protein (Surface antigen) (a.a.29 to 389)	Q9A147	100 µg	1195	Order
PP0987	Recombinant Protein-Streptococcus pyogenes serotype M12 M protein 12 (a.a.41 to 575)	Q1JJR2	100 µg	1195	Order
PP0988	Recombinant Protein-Streptococcus pyogenes serotype M2 Myosin-crossreactive antigen (a.a.22 to 322)	Q1JI72	100 µg	1195	Order
PP0989	Recombinant Protein-Streptococcus pyogenes serotype M2 M protein 2 (a.a.61 to 460)	Q1JFU4	100 µg	1195	Order
PP0990	Recombinant Protein-Streptococcus pyogenes 67 kDa antigen (a.a.35 to 335)	Q48UX1	100 µg	1195	Order
PP0991	Recombinant Protein-Streptococcus pyogenes M28_Spy0697 (a.a.21 to 328)	Q48TZ6	100 µg	1195	Order
PP0992	Recombinant Protein-Streptococcus pyogenes serotype M28 UPF0348 protein (a.a.21 to 368)	Q48V83	100 µg	1195	Order
PP0993	Recombinant Protein-Streptococcus pyogenes serotype M3 Mitogenic factor (a.a.31 to 264)	Q8K6X0	100 µg	1195	Order
PP0994	Recombinant Protein-Streptococcus pyogenes serotype M3 surface antigen (a.a.61 to 460)	Q8K7X8	100 µg	1195	Order
PP0995	Recombinant Protein-Streptococcus pyogenes serotype M4 Antigen A (a.a.53 to 167)	Q1CP96	100 µg	1195	Order
PP0996	Recombinant Protein-Streptococcus pyogenes serotype M4 Antigen B (a.a.21 to 136)	Q1CP97	100 µg	1195	Order
PP0997	Recombinant Protein-Streptococcus pyogenes serotype M4 Antigen C (a.a.21 to 131)	Q1CP98	100 µg	1195	Order
PP0998	Recombinant Protein-Streptococcus pyogenes serotype M4 M protein 4 (a.a.41 to 388)	Q1J4H6	100 µg	1195	Order
PP0999	Recombinant Protein-Streptococcus pyogenes 67 kDa antigen (a.a.21 to 321)	B5XK69	100 µg	1195	Order
PP1000	Recombinant Protein-Streptococcus pyogenes serotype M49 M protein serotype 49 (a.a.41 to 389)	P16947	100 µg	1195	Order
PP1001	Recombinant Protein-Streptococcus pyogenes serotype M49 Streptodornase B-Mitogenic factor 1 (a.a.42 to 276)	B5XIU6	100 µg	1195	Order
PP1002	Recombinant Protein-Streptococcus pyogenes serotype M5 M protein serotype 5 (a.a.31 to 492)	A2RGM0	100 µg	1195	Order
PP1003	Recombinant Protein-Streptococcus pyogenes serotype M6 M protein serotype 6 (a.a.41 to 483)	P08089	100 µg	1195	Order
PP1004	Recombinant Protein-Streptococcus pyogenes serotype M6 Trypsin-resistant surface T6 protein (a.a.23 to 537)	P18481	100 µg	1195	Order
RPP0968	cDNA-Streptococcus pyogenes Fibronectin-fibrinogen-binding protein (a.a.61 to 474)	Q6SPC7	2 µg	2065	Order
RPP0969	cDNA-Streptococcus pyogenes Fibronectin-binding protein II (a.a.61 to 460)	P72532	2 µg	1995	Order
RPP0970	cDNA-Streptococcus pyogenes M protein (a.a.22 to 220)	B7TBG7	2 µg	990	Order
RPP0971	cDNA-Streptococcus pyogenes M protein 11 (a.a.41 to 386)	Q54829	2 µg	1725	Order
RPP0972	cDNA-Streptococcus pyogenes M protein 19 (a.a.41 to 558)	Q54718	2 µg	2585	Order
RPP0973	cDNA-Streptococcus pyogenes M protein 3 (a.a.41 to 581)	Q54835	2 µg	2700	Order
RPP0974	cDNA-Streptococcus pyogenes M protein 55 (a.a.41 to 550)	Q54840	2 µg	2545	Order
RPP0975	cDNA-Streptococcus pyogenes M protein type 41 (a.a.39 to 408)	Q54837	2 µg	1845	Order
RPP0976	cDNA-Streptococcus pyogenes M protein type 52 (a.a.33 to 436)	Q54839	2 µg	2015	Order
RPP0977	cDNA-Streptococcus pyogenes M protein type 83 (a.a.24 to 85)	Q5XPU8	2 µg	305	Order
RPP0978	cDNA-Streptococcus pyogenes M protein serotype 2.1 (a.a.40 to 407)	P50468	2 µg	1835	Order
RPP0979	cDNA-Streptococcus pyogenes M protein serotype 2.2 (a.a.33 to 372)	P50469	2 µg	1695	Order
RPP0980	cDNA-Streptococcus pyogenes M protein serotype 24 (a.a.41 to 539)	P12379	2 µg	2490	Order
RPP0981	cDNA-Streptococcus pyogenes M18 protein 18 (a.a.41 to 437)	Q9AMC4	2 µg	1980	Order
RPP0982	cDNA-Streptococcus pyogenes Mitogenic factor (a.a.32 to 271)	Q54969	2 µg	1195	Order
RPP0983	cDNA-Streptococcus pyogenes M-type 9 protein (a.a.33 to 384)	Q54841	2 µg	1755	Order
RPP0984	cDNA-Streptococcus pyogenes steptococcal M PAM (a.a.25 to 388)	P49054	2 µg	1815	Order
RPP0985	cDNA-Streptococcus pyogenes serotype M1 M protein type 1 (a.a.35 to 484)	Q99XV0	2 µg	2245	Order
RPP0986	cDNA-Streptococcus pyogenes serotype M1 42 kDa protein (Surface antigen) (a.a.29 to 389)	Q9A147	2 µg	1800	Order
RPP0987	cDNA-Streptococcus pyogenes serotype M12 M protein 12 (a.a.41 to 575)	Q1JJR2	2 µg	2670	Order
RPP0988	cDNA-Streptococcus pyogenes serotype M2 Myosin-crossreactive antigen (a.a.22 to 322)	Q1JI72	2 µg	1500	Order
RPP0989	cDNA-Streptococcus pyogenes serotype M2 M protein 2 (a.a.61 to 460)	Q1JFU4	2 µg	1995	Order
RPP0990	cDNA-Streptococcus pyogenes 67 kDa antigen (a.a.35 to 335)	Q48UX1	2 µg	1500	Order
RPP0991	cDNA-Streptococcus pyogenes M28_Spy0697 (a.a.21 to 328)	Q48TZ6	2 µg	1535	Order
RPP0992	cDNA-Streptococcus pyogenes serotype M28 UPF0348 protein (a.a.21 to 368)	Q48V83	2 µg	1735	Order
RPP0993	cDNA-Streptococcus pyogenes serotype M3 Mitogenic factor (a.a.31 to 264)	Q8K6X0	2 µg	1165	Order
RPP0994	cDNA-Streptococcus pyogenes serotype M3 surface antigen (a.a.61 to 460)	Q8K7X8	2 µg	1995	Order
RPP0995	cDNA-Streptococcus pyogenes serotype M4 Antigen A (a.a.53 to 167)	Q1CP96	2 µg	800	Order
RPP0996	cDNA-Streptococcus pyogenes serotype M4 Antigen B (a.a.21 to 136)	Q1CP97	2 µg	800	Order
RPP0997	cDNA-Streptococcus pyogenes serotype M4 Antigen C (a.a.21 to 131)	Q1CP98	2 µg	800	Order
RPP0998	cDNA-Streptococcus pyogenes serotype M4 M protein 4 (a.a.41 to 388)	Q1J4H6	2 µg	1735	Order
RPP0999	cDNA-Streptococcus pyogenes 67 kDa antigen (a.a.21 to 321)	B5XK69	2 µg	1500	Order
RPP1000	cDNA-Streptococcus pyogenes serotype M49 M protein serotype 49 (a.a.41 to 389)	P16947	2 µg	1740	Order
RPP1001	cDNA-Streptococcus pyogenes serotype M49 Streptodornase B-Mitogenic factor 1 (a.a.42 to 276)	B5XIU6	2 µg	1170	Order
RPP1002	cDNA-Streptococcus pyogenes serotype M5 M protein serotype 5 (a.a.31 to 492)	A2RGM0	2 µg	2305	Order
RPP1003	cDNA-Streptococcus pyogenes serotype M6 M protein serotype 6 (a.a.41 to 483)	P08089	2 µg	2210	Order
RPP1004	cDNA-Streptococcus pyogenes serotype M6 Trypsin-resistant surface T6 protein (a.a.23 to 537)	P18481	2 µg	2570	Order

Please contact us for a quote on larger sizes …

Streptococcus pyogenes cDNA and recombinant antigen

Codon-optimized cDNA is cloned into E. coli expression vector with 6x His-tag at N-terminus and ready-to-use for recombinant protein production.
Recombinant protein applications: Western Blot may be used for other applications determined by the user.
Protein Purity: >90%, as determined by SDS-PAGE under reducing conditions.
Protein Activity: N/A
Protein Tag: Contains A 6x histidine tag at N-terminus.
Protein Formulation: Liquid
Source: Produced from E. coli

Streptococcus pyogenes is a bacterium that causes various diseases, including strep throat, scarlet fever, and invasive infections such as sepsis and necrotizing fasciitis. The bacterium has many virulence factors that contribute to its pathogenicity, including several surface proteins that enable it to interact with host cells and tissues.

One such protein is the fibronectin-fibrinogen-binding protein, which binds to fibronectin and fibrinogen, two important components of the extracellular matrix. Another fibronectin-binding protein, known as M protein or protein F, is a major virulence factor that helps the bacterium evade host immune defenses. There are many different types of M protein, each of which is encoded by a different gene and confers a specific serotype.

Some of the most common serotypes of S. pyogenes include M1, M3, M4, M5, M6, and M12. Each of these serotypes has a unique set of surface antigens and virulence factors that contribute to its ability to cause disease. For example, the M1 serotype is associated with severe invasive infections such as necrotizing fasciitis, while the M4 serotype is often associated with strep throat and scarlet fever.

Other surface proteins produced by S. pyogenes include the mitogenic factor, which stimulates cell division and growth, and the choline-binding proteins, which are involved in cell wall synthesis and adherence to host cells. The bacterium also produces an immunoglobulin A1 protease, which cleaves immunoglobulin A1 antibodies and enables the bacterium to evade host immune defenses.

In addition to these surface proteins, S. pyogenes also produces a thiol-activated cytolysin known as pneumolysin, which contributes to the bacterium’s ability to damage host tissues and cause disease. Finally, the bacterium produces several myosin-crossreactive antigens, which can trigger an autoimmune response in some individuals and contribute to the development of rheumatic fever.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E. coli expression Vector), which are ready for production of the recombinant proteins.

Streptococcus pyogenes cDNA and recombinant antigen can be applied in various ways. The cDNA can be used for cloning and expression of proteins, as well as for constructing gene libraries and identifying novel proteins. The recombinant antigen can be used for developing diagnostic assays, vaccines, and therapeutic targets. Additionally, the recombinant antigen can be used to identify and characterize new strains of S. pyogenes. Furthermore, the recombinant antigen can be used to study the molecular basis of interactions between S. pyogenes and host cells in order to develop new treatments for the bacteria.

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Streptococcus pyogenes cDNA and recombinant antigen

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