Human adenovirus A cDNA and Antigen

Human adenovirus A is a type of virus that can cause a range of illnesses in humans, including respiratory infections, eye infections, and gastroenteritis. Some adenoviruses can also cause more serious illnesses, such as meningitis or pneumonia. The virus is highly contagious and spreads through close contact with an infected person or through contact with contaminated surfaces. There is no specific cure for adenovirus infections, but symptoms can be managed with rest, hydration, and over-the-counter medications.

The human adenovirus A genome is the complete genetic material of the virus, which consists of a double-stranded DNA molecule. The genome is organized into a series of genes that encode various viral proteins involved in replication, virulence, and evasion of host immune responses. The size of the adenovirus genome varies depending on the specific strain of the virus, but typically ranges from approximately 36 to 50 kilobases. The genetic information in the adenovirus genome is used to direct the replication of the virus, to produce new viral particles, and to infect new host cells. Understanding the adenovirus genome is important for developing antiviral therapies and vaccines to prevent adenovirus infections.

Adenovirus antigen is a substance that is produced by a human adenovirus A infection and that can be detected in a laboratory test. The presence of adenovirus antigens indicates that a person is infected with the virus. Antigen tests are commonly used to diagnose adenovirus infections, as well as to monitor the progression of the infection and to determine whether a patient is no longer contagious. These tests work by detecting proteins on the surface of the virus, and they are generally quick, simple, and highly accurate.

Human adenovirus A, serotype 12 is a type of adenovirus that infects humans. It contains various proteins that play important roles in the virus’s life cycle and interaction with the host cell.

The Early E2A DNA-binding protein is a transcription factor that binds to DNA and regulates the expression of other viral genes. The large T-antigen is a multifunctional protein that plays a key role in viral replication and transformation of infected cells. The E1B protein is also involved in viral replication and can inhibit host cell apoptosis.

The Early E3B 12.7 kDa protein is a non-structural protein that plays a role in immune evasion by inhibiting the host cell’s immune response. The Late 100 kDa protein is a structural protein that is a major component of the viral capsid. Maturation protein IVa2 is involved in the assembly and maturation of the viral capsid.

The Minor core protein is a structural protein that forms the core of the viral particle. The E1A 13S protein is a transcriptional activator that regulates the expression of both viral and cellular genes. The 52K homolog protein is a non-structural protein that plays a role in viral DNA replication. The PVII protein is a structural protein that is a component of the viral capsid.

The 33K homologue protein and 22K homologue protein are both non-structural proteins that are involved in viral DNA replication. The 34K protein is a non-structural protein that plays a role in the transport of viral proteins to the nucleus. The E4 13K homologue protein and E4 11K homologue protein are both non-structural proteins that play a role in viral DNA replication and inhibition of host cell apoptosis.

The use of recombinant proteins/cDNA in academic research and therapeutic applications has skyrocketed. However, in heterologous expression systems, successful recombinant protein expression is dependent on a variety of factors, including codon preference, RNA secondary structure, and GC content. When compared to pre-optimization, more and more experimental results demonstrated that the expression level was dramatically increased, ranging from two to hundred times depending on the gene. Bioclone has created a proprietary technology platform that has resulted in the creation of over 6,000 artificially synthesized codon-optimized cDNA clones (cloned in E.coli expression Vector), which are ready for production of the recombinant proteins.